CiviCRM works with Drupal (4.7 and 5.x) or Joomla . Currently, CiviCRM is better integrated into Drupal.

New with release 2.0 of CiviCRM is the ability to use it with any CMS (or no CMS at all). What this means is that CiviCRM runs all by itself without a Drupal or Joomla installation. This feature is referred to as "standalone," and now you can try it out! The new standalone demo server is live at:

http://standalone.demo.civicrm.org/

For more information, see Install 2.0 for Standalone and http://www.nabble.com/Announcing-CiviCRM-Standalone-demo-server-to15492457s15986.html .